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When handcuffing a suspect, it is essential to prioritize officer safety and the control of the suspect. Securing the dominant wrist first—often the right wrist for a majority of individuals—generally allows the officer to maintain better control over the subject, as it makes it more difficult for an individual to escape or resist. By beginning with the dominant wrist, the officer can also use their free hand to monitor the suspect's movements and prepare to secure the other wrist quickly.

In certain situations, beginning with the left wrist or using both wrists simultaneously may be appropriate based on the environment or the behavior of the suspect. However, the standard practice typically emphasizes securing the dominant wrist first to maximize control and ensure the safety of the officer and the suspect. This approach helps establish a more secure position before moving to the secondary wrist.